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GIST College student Yongseok Choi receives a special award at the 5th EDISON competition
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- REG_DATE : 2016.04.21
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GIST College student Yongseok Choi receives
a special award at the 5th EDISON competition
GIST College student Yongseok Choi has won the Chairman"s Prize in the computational chemistry division of the 5th EDISON SW competition for his research paper entitled: "Zika Virus: Discovering Effective Protease Inhibitors via Template-Based Modeling."
The EDISON competition was organized by the Korea Research Foundation to promote creative thinking and problem-solving skills among students. The EDISON competition is divided into five divisions: Computational Fluid Dynamics, Computational Nanophysics, Computational Chemistry, Computational Structural Dynamics, and Computer Aided Optimal Design.
With the devastating spread of the Zika virus in Brazil and its association with birth defects and microcephaly, Yongseok Choi"s paper investigated the Zika virus’s nonstructural proteins with template-based modeling by using GalaxyTBM/Refine/SC. He then used GalaxyDock to examine the effectiveness of various known serine protease inhibitors to inhibit the Zika viral protease. After testing five inhibitors,
Yongseok Choi"s paper concluded that the Kunitz soybean trypsin inhibitor showed the strongest binding affinity (-10.082 kcal/mol). His paper provides a rudimentary foundation for further drug discovery research regarding the Zika virus.
Participants in the EDISON competition were required to base their research on computational science and engineering software associated EDISON.