Professor Jae Gwon Kim's research team monitors ultrasonic brain stimulation using optical imaging
□ A research team led by Professor Jae Gwon Kim of the Department of Biomedical Science and Engineering at the Gwangju Institute of Science and Technology (GIST, President Seung Hyeon Moon) used optical imaging technology to monitor the effects of ultrasound brain stimulation and has proposed techniques for optimizing ultrasound brain stimulation conditions.
∘ The results of this study will contribute to the development of ultrasonic brain stimulation technology by monitoring the effects of ultrasound brain stimulation with optical imaging technology.
□ Although various brain stimulation techniques have been reported to be effective for diseases such as Parkinson's disease, severe depression, and obsessive-compulsive disorder, tachycardia or transthoracic stimulation techniques having difficulty in stimulating specific areas and also require surgery. On the other hand, ultrasonic brain stimulation technique is more promising in that it can stimulate specific parts of the brain relatively non-invasively and many related studies have recently been published.
□ To observe the brain stimulation effect, electrical brain signals such as EEG * and cerebral hemodynamics and brain metabolic imaging techniques such as fMRI * or PET * have been applied. However, because they have high spatial resolution despite relatively low cost, other techniques are needed to monitor brain stimulation effects. Therefore, Professor Jae Gwon Kim's research team observed the hemodynamic changes in the brain during ultrasonic brain stimulation by applying optical intrinsic signal imaging (OISI), * which can observe brain function in high resolution within a wide area.
* Electroencephalogram (EEG) is one of the most commonly used techniques in brain research to measure electrical signals generated when the brain is activated.
* Functional Magnetic Resonance Imaging (fMRI) is a technique that uses magnetic field signals that change depending on the oxygen concentration of the hemoglobin in the blood.
* Positron Emission Tomography (PET) is a technique that uses the radiation emitted from a human body for imaging.
* Optical Intrinsic Signal Imaging (OISI) can acquire tissue oxygen saturation and blood volume information by irradiating light into human body tissue and measure the reflected light.
□ The research team constructed an OISI imaging system to acquire cerebral hemodynamic images and observed the presence or absence of a brain stimulation effect according to the frequency of the ultrasonic stimulation. The hemodynamic changes in the brain were different according to the pulse repetition period even at the same frequency. In addition, the observed cerebral hemodynamic changes were divided into two components by applying the PCA method. The cerebral hemodynamic signals were different according to each component, and the laser speckle images showed similar changes in blood flow velocity during ultrasonic stimulation.
* Principal Component Analysis (PCA) is a statistical method that converts high-dimensional data into low-dimensional data.
□ Professor Jae Gwon Kim said, " This study shows that it is possible to observe the effect of brain stimulation using ultrasound optical imaging technology, and it will help to develop and optimize ultrasound brain stimulation technology in the future."
∘ Professor Jae Gwon Kim also participated in the "Development of multi-biomedical information-based dementia severity monitoring technology" with Professor Jong-In Song of the School of Electrical Engineering and Computer Science at the Optimal Dementia Management Technology Research Center and has been accelerating the development of patient-friendly dementia severity monitoring technology using EEG and optical technology.
